ashwagandha and coumadin interaction
Phytotherapy Research 1989;3(5):201-206. Medically reviewed by Leigh Ann Anderson, PharmD. 2021 Nov 25;13(2):100510. PLoS One 2009;4:e6628. Does methotrexate interact with my other drugs? From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Ashwagandha May Interact With Certain Drugs Ashwagandha may interact with certain drugs by enhancing or negating their actions. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25. Richards JS. It is also promoted for depression, premenstrual syndrome (PMS), menopause symptoms, and headaches. View abstract. However, the practical benefits and risks for people aren't clear yet. Bethesda, MD 20894, Web Policies ConsumerLab.com's answer explains. WebMD says it can interact with thyroid medicine, anti depressants, and immunosuppressants, it doesn't list any blood thinners (link at https://www.webmd.com/vitamins/ai/ingredientmono-953/ashwagandha) direebn 3 days ago View abstract. Consult your health care provider before taking if you are pregnant or nursing, or have any other medical conditions. Always consult with your doctor or pharmacist to check for herbal and drug interactions with any medicines you take. April 25, 2022 Becoming a Vegetarian: Foods to Choose From. Syst Rev. Taking ashwagandha along with diabetes medications might cause blood sugar to drop too low. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. levothyroxine, desiccated thyroid) could potentially increase thyroid hormone levels too much, increasing the risk of side effects. Comments will be approved before showing up. Indian J Exp Biol. In general, Ashwagandha is thought to be safe when used in moderate amounts. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Most clinical research supports valerian's use to relieve insomnia and improve sleep quality. As a medication, Lexapro does have a list of other medicines where interaction is possible. View abstract. J Ethnopharmacol 1999;67:233-39. While avoidance of medications in pregnancy is the best course of action, this is not Society tends to treat menopause as a disease; something to be avoided at all costs. OTHER NAME(S): Ajagandha, Amangura, Amukkirag, Asan, Asana, Asgan, Ashwagandha has most often been used by adults in doses up to 1000 mg daily, for up to 12 weeks. Immunomodulatory and CNS effects of sitoindosides 9 and 10, two new glycowithanolides from Withania somnifera. Minor potentiation was defined as an INR that does not require a dosage adjustment. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Lets dive in: Looking for a tasty product that takes advantage ofmedicinal mushroom and nootropic ingredientslikethis? I have it on my medical HelloPharmacist Journal of Research in Ayurveda and Siddha 1980;1(2):247-258. As an adaptogen, helping the body resist physiological and psychological stress, Steroidal lactones (withanolides, withaferins), GLP-1 Agonists (e.g. Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study. 1998;20(1):191-198. I always check for drug interactions. Remember that herbal supplements are not subject to FDA oversight and have not usually been tested in clinical studies to prove their effectiveness or safety. Sriranjini SJ, Pal PK, Devidas KV, Ganpathy S. Improvement of balance in progressive degenerative cerebellar ataxias after Ayurvedic therapy: a preliminary report. A systematic review and meta-analysis of randomized controlled trials. Praveenkumar, V., Kuttan, R., and Kuttan, G. Chemoprotective action of Rasayanas against cyclosphamide toxicity. MedFacts Natural Products. 2021 Jul 30;100(30):e26809. Answer (1 of 8): 12 Proven Health Benefits of Ashwagandha and Ashwagandha: It's Powerful Health and Beauty Benefits You Didn't Know About and Ashwagandha: Health benefits and side effects Ashwagandha itself works as a antidepressant. 1965;9(1):9-15. Antiplatelet drugs such as clopidogrel; NSAIDs such as ibuprofen; Blood thinners such as warfarin Biochem.Biophys.Res Commun. Taking small doses - up to 250mg - of ashwagandha alongside your caffeine can help balance out the effects of both. Symptoms of an allergic reaction to Ashwagandha may include: In some cases, herbal remedies can interact with certain medications, including other supplements and OTC and prescription drugs. View abstract. While usually well-tolerated, important drug interactions can occur. Ashwagandha is probably unsafe for pregnant women because it might increase the risk of miscarriage. View abstract. Due to the seriousness of many drug interactions, you should consult with your health care provider before using St. John's Wort. Ireland PJ, Hardy T, Burt AD, Donnelly MC. Effect of Asian ginseng, Siberian ginseng, and Indian ayurvedic medicine Ashwagandha on serum digoxin measurement by Digoxin III, a new digoxin immunoassay. Two of the more serious interactions with goldenseal can occur with certain antipsychotic drugs. Sud Khyati S, Thaker B. View abstract. L-Theanine vs L-Tyrosine: Comparing Benefits, Side Effects & More, L-Theanine and Caffeine: The Nootropic Stack Your Mornings Need, Best Lions Mane Supplement: Everything to Consider. Keep out of reach of children. Otherwise, side effects are both rare and mild and can usually be remediated by adjusting your dosing routine. 2021 Nov 30;2021:8254344. Indian J Exp Biol. Cranberry may exert an increased effect on blood thinners (anticoagulants) like warfarin and lead to bruising or bleeding. View abstract. Effect of Ashwagandha (Withania somnifera Dunal) on the process of ageing on human volunteers. Devi, P. U., Sharada, A. C., and Solomon, F. E. In vivo growth inhibitory and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma. Sehgal, V. N., Verma, P., and Bhattacharya, S. N. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. Please enable it to take advantage of the complete set of features! Sleep Med. Ginseng has been used in Asian countries for its therapeutic effects for centuries. Change in balance, feeling shaky, or unsteady, Not able to think clearly or change in thinking, US Department of Defense Dietary Supplement Resource, https://www.opss.org/article/ashwagandha-dietary-supplement-products, This generalized information is a limited summary of diagnosis, treatment, and/or medication information. View abstract. Below are some examples of supplements that may potentially interact with warfarin (more details can be found by clicking on the links): View abstract. Nevertheless there is a theoretical risk for potentiation, since the herb is thought to be a coumarin constituent. 2009;15(4):423-430. J Clin Med 2021;10(16):3644. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Cancer Lett. Assessment of Withania somnifera root extract efficacy in patients with generalized anxiety disorder: A randomized double-blind placebo-controlled trial. J Ethnopharmacol 1999;64:91-3. Clot survivors is a support group for people who have survived blood clots. View abstract. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. 2020;40(4):825-829. Ashwagandha might lower blood pressure. Copyright 2023 UpToDate, Inc. and its affiliates and/or licensors. 2002 Sep 2;164(36):4161-5. Herbal supplements are not subject to review by the FDA and their use can often be risky. 2004;42(12):2015-2020. In a review article published in March 2014, 38 herbs were reviewed and were found to clinically interact with warfarin. MAOIs are typically only used when other antidepressants have proven ineffective because they have a higher risk of drug interactions than standard antidepressants. Do not stop any medicines unless approved by your healthcare provider. Be sure to tell your doctor if you are breastfeeding. PMC Ginkgo has been promoted to be used for treating anxiety, dementia, circulation problems in the legs, premenstrual sydrome, certain vision problems, dizziness, or some movement disorders. 8 min read. Katz M, Levine AA, Kol-Degani H, Kav-Venaki L. A compound herbal preparation (CHP) in the treatment of children with ADHD: a randomized controlled trial. Often, patients do not inform their providers about the use of herbal products; this can significantly hinder patient care and adverse event reporting. Chauhan S, Srivastava MK, Pathak AK. View abstract. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. Deshpande A, Irani N, Balkrishnan R, Benny IR. View abstract. Ashwagandha may have additive effects to certain drugs that are used for diabetes, high blood pressure, and low thyroid hormone, to name a few. J Ethnopharmacol. There aren't any specific antidiabetic drugs ashwagandha is known to interact with. Go to the ER right away. View abstract. View abstract. Clinical characteristics, prescription patterns, and persistence associated with sacubitril/valsartan adoption: A STROBE-compliant study. The body naturally produces thyroid hormones. Available for Android and iOS devices. The root and berry of the ashwagandha plant are a traditional Ayurvedic medicine in India. All information is observation-only. It may cause you to become sleepy or drowsy. Major inhibition was defined by the signs of thrombosis, while moderate inhibition was defined by INRs that required a warfarin dosage adjustment. J Obstet Gynaecol Res 2021. We can, however, make some educated guesses on drug interactions based on ashwagandha works, and the effects it is known to have. Withania somnifera extract. Safe For Diabetics? In our latest question and answer, the pharmacist discusses whether or not ashwagandha supplements interact with prescription drugs. Diarrhea. Integr Cancer Ther. Association of l-DOPA with recovery following Ayurveda medication in Parkinson's Disease. One study, published in Phytotherapy Research, reported that ashwagandha supplementation reduced blood sugar and A1c levels, although this was a relatively small study. Select a condition to view a list of vitamins. Choudhary D, Bhattacharyya S, Joshi K. Body weight management in adults under chronic stress through treatment with ashwagandha root extract: a double-blind, randomized, placebo-controlled trial. The FDA can and does seize and remove from the market tainted, contaminated, fraudulent or unsafe dietary supplements when they are aware of problems. Take extra care if you are at a high risk for infection. Always check with your doctor before you use a natural product. Kelgane SB, Salve J, Sampara P, Debnath K. Efficacy and tolerability of ashwagandha root extract in the elderly for improvement of general well-being and sleep: A prospective, randomized, double-blind, placebo-controlled study. Ashwagandha side effects While the side effects of ashwagandha are minimal, some people may experience: Gastrointestinal upset. It seemed high to me too, when I asked for beta blockers, my doctor said he'd prescribe 40mg, to which I replied 'that seems a bit high, I read online that 10mg-20mg is effective for public speaking', but he just shook his head and said 'you wouldn't even be able to . Fuladi S, Emami SA, Mohammadpour AH, Karimani A, Manteghi AA, Sahebkar A. 1996;35(1):95-100. Sign up to be the first to knowabout sales, product additions, news & more! Taking ashwagandha along with these medications might decrease the effects of these medications. View abstract. It is high in iron and has been shown to help increase hemoglobin levels. More research is needed to understand how this may work, but Ashwagandha may be able to reduce cortisol levels to help balance blood pressure and heart rate. Indian J Psychol Med. Do not use this product if you have stomach problems or ulcers. Drugs.com. Ashwagandha has not been linked to weight gain in any significant capacity. Ashwagandha might increase how much thyroid hormone the body produces. Yes, the effectiveness of warfarin (Coumadin), anisindione (Miradon) and other anticoagulant drugs prescribed to help prevent blood clots can be impacted by taking supplements. There are over 180 drug interactions with garlic, but most are reported as minor. 2019;98(37):e17186. Currently on week 5 20mg Prozac and 600mg ksm-66 ashwagandha daily. Arch Pathol Lab Med 2007;131:1298-303. You may need to have your blood clotting tests checked more frequently and may need a change in your anticoagulant dose. This product may cause you to be sleepy. Available for Android and iOS devices. Epub 2019 Jan 28. Singh, R. H., Narsimhamurthy, K., and Singh, G. Neuronutrient impact of Ayurvedic Rasayana therapy in brain aging. Acta Pol.Pharm. The use of this information is governed by the Terms of Use, available at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms. Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? No more monthly mood swings, period accidents, or pregnancy worries. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. Gopal S, Ajgaonkar A, Kanchi P, et al. 1985;23(4):177-183. All rights reserved. Davis, L. and Kuttan, G. Effect of Withania somnifera on DMBA induced carcinogenesis. Animal studies have found that ashwagandha could boost the effects of radiation therapy. View abstract. 2021 Feb 11;6(1):20. doi: 10.3390/jfmk6010020. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. A randomized double blind placebo controlled study of ashwagandha on generalized anxiety disorder. Ashwagandha might help lower blood sugar in people with type 2 diabetes and lower high cholesterol. HHS Vulnerability Disclosure, Help Concerns Taking Wellbutrin For Panic Attacks, Questions About A High Dosage Of Amoxicillin For A Child With Strep Throat. 2023 eHealthMe.com. Therefore, it should be used cautiously with drugs used to treat diabetes, including: Just like with potential interactions between ashwagandha and diabetes drugs, there may be a potential issue with drugs used to treat high blood pressure as studies show ashwagandha mayhave blood-pressure-lowering effects. View abstract. J Res Ayur Sid 1980;1:370-385. This product may interfere with some lab tests. These products are intended for use and purchase only by persons 21 and older as in selected States. Because it can be affected by a large number of herbs, supplements and foods, it's important to consult your physician before taking any supplement with warfarin. Food Chem.Toxicol. January 03, 2023 All rights reserved. Be sure to tell your doctor that you take this product if you are scheduled for surgery or tests. Akhgarjand C, Asoudeh F, Bagheri A, et al. Singh P, Salman KA, Shameem M, Warsi MS. Withania somnifera (L.) Dunal as add-on therapy for COPD patients: a randomized, placebo-controlled, double-blind study. View abstract. Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study. Products containing kava may cause liver problems, and taking them with alcohol can increase the risk. If you make a positive or negative comment about a product, note whether or not you have a financial interest in the product or in a competing product. There is no drug interaction reported. There are many other possible garlic supplement interactions, so be sure to review all possible drug interactions with garlic and speak with your healthcare provider. Federal government websites often end in .gov or .mil. Others mix 3 grams of ashwagandha powder in warm milk. Be sure to talk with your doctor about this and all drugs you are taking, especially digoxin. 1988;26(11):877-882. Some medications, such as those used after a transplant, decrease the activity of the immune system. Phytotherapy Research 1991;5:111-114. People use ashwagandha for other health conditions, including anemia. darius the destroyer record / how to change facebook color back to normal / ashwagandha and coumadin interaction. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. O'Connor J, Lindsay K, Baker C, Kirby J, Hutchins A, Harris M. The impact of ashwagandha on stress, sleep quality, and food cravings in college students: quantitative analysis of a double-blind randomized control trial. Taking ashwagandha along with medications that lower blood pressure might cause blood pressure to go too low. Examples of important medicines extracted from botanicals include reserpine, morphine, penicillin, and vinca alkaloid anti-cancer drugs. Information from this source is evidence-based and objective, and without commercial influence. Arch Intern Med 1998:158;2200-11. Front Pharmacol 2022;13:901710. Learn more about the possible counteractive effects of CoQ10 and blood thinners, including safety. Ashwagandha is used as a tonic (it is sometimes referred to as the Indian ginseng) to improve physical and mental health and to treat a number of specific conditions. We recommend checking outLucid Super Coffee. Enter other medications to view a detailed report. Interactions of clinical relevance associated with concurrent administration of prescription drug and food or medicinal plants: a systematic review protocol. Liver Int. Kumar S, Bouic PJ, Rosenkranz B. and transmitted securely. We study 132,077 people who take Ashwagandha or Coumadin. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). I suffer from depression, stress and anxiety but I Can I take Benadryl (Diphenhydramine) and Claritin (Loratadine) together? I want I have bad allerg Can a diabetic who is dehydrated take oral rehydration sachets? Phytother Res. Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. Kumar G, Srivastava A, Sharma SK, Rao TD, Gupta YK. The references on the analyzed literature have been investigated in order to collect the existing data. glipizide, glyburide, glimepride), SGLT2 Inhibitors (e.g. Over-the-counter supplements are not approved for safety or effectiveness by the FDA before they hit the market, and some may contain tainted chemicals or even illegal prescription drugs. You may need to have your International Normalized Ratio (INR) or other blood clotting lab test checked more frequently, or have your warfarin dose changed. Please do not submit any type of HTML markup or scripting as it will not be accepted, nor will posts that exceed 2,500 characters. Epub 2016 Jun 17. Your last name and email address will not be displayed. Other drugs that have the same active ingredients (e.g. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Ashwagandha contains a class compounds called withanolides, which may help reduce stress and inflammation while boosting immune system activity in the body. Press question mark to learn the rest of the keyboard shortcuts, https://www.webmd.com/vitamins/ai/ingredientmono-953/ashwagandha. View abstract. Of the total drug interactions, 74 are major, 250 are moderate, and 2 are minor. Valerian has been used to treat insomnia and anxiety, and people often use it for this effect. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. Today, ginseng use is reported to improve the body's resistance to stress and increase vitality, among other uses. Take extra care and check with your doctor if you have: Signs of a very bad reaction. 2005 - 2023 WebMD LLC. Pharmacokinetic Interactions between Cardiovascular Medicines and Plant Products. 2020;12(4):1119. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults. Careers. I felt almost godlike with how comfortable I was at the podium. View abstract. Nonetheless, always check with your doctor or pharmacist for a drug interaction screen. Yes, taking ashwagandha daily is safe, but you should work with your doctor to create a dosing routine that works with your current wellness plan and health goals. Contact your health care provider if you discover that a possible drug interaction may occur between medications and herbal products that you use. Updates on the clinical evidenced herb-warfarin interactions. Malhotra, C. L., Mehta, V. L., Das, P. K., and Dhalla, N. S. Studies on Withania-ashwagandha, Kaul. The interactions between warfarin and medicinal herbs described in the literature have been summarized in this paper relying on Medline database (via PubMed) using the key words: warfarin, herbal supplements and interactions. 3 min read. On xarelto, I've used plenty of herbs, including ashwagandha with no problems. Remenapp A, Coyle K, Orange T, et al. These statements have not been evaluated by the Food and Drug Administration. We comply with the HONcode standard for trustworthy health information. This is especially problematic in the use of medications with narrow therapeutic indices, such as warfarin. You can also connect with Dr. Brian Staiger on LinkedIn. Effect of standardized root extract of ashwagandha (Withania somnifera) on well-being and sexual performance in adult males: a randomized controlled trial. They do list some herbs in the drug interactions section (e.g., St. John's Wort) but ashwagandha is not listed. Many sources are quick to cover Ashwagandhas potential benefits, and rightfully somodern evidence suggest that the herbal remedy may be useful for managing anxiety, lowering pain and inflammation, and improving heart health. In some parts of the world, people eat ashwagandha shoots, seeds, and fruit. View abstract. View abstract. Indian J Exp Biol 1997;35:236-9. Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. CoQ10 is promoted may be effective for migraines, heart conditions like high blood pressure or heart failure, Parkinson's disease or macular degeneration, but you shuld only take CoQ10 for these conditions if recommedned by your health care provider. View abstract. It is important to remember that the best way to handle any possible drug interaction is to predict it and prevent it. Examples of drugs that may interfere include: Call your doctor at once if you have signs of bleeding such as: swelling, pain, dizziness, weakness, bleeding gums, nosebleeds, heavy menstrual periods or abnormal vaginal bleeding, blood in your urine, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds, or any bleeding that will not stop. Health Sci Rep 2022;5(4):e741. Ashwagandha has not been well studied in regard to potential interactions with prescription medication. Enter other medications to view a detailed report. Garlic supplements are sold over-the-counter, usually in tablet or capsule form. Personalize this study to your gender and age, Pramipexole Dihydrochloride and Abnormal Behavior, Rapamune and Left Ventricular Hypertrophy, Lantus Solostar and Vitamin E drug interaction, Gastroenteritis Pseudomonas and drugs of ingredients of prednisone. What are the Side Effects of Ashwagandha? Are there supplements I should avoid, or be taking, due to this drug? Although data regarding the effect of gamma linolenic acid on seizure threshold are conflicting and limited, use of evening primrose oil may increase the risk for seizures if taken with other drugs that can lead to seizure risk. First and foremost, I want to point out this it can tricky to determine whether or not a dietary/herbal supplement will interact with prescription drugs due to a general lack of studies on the matter. 2018 Mar;24(3):243-248. generic drugs) are not considered. Different individuals may respond to medication in different ways. Choline vs Alpha-GPC: Which is the Superior Cholinergic? Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. Its effect on arterial blood pressure in anaesthetized dogs. Taking ashwagandha with thyroid hormone pills might cause too much thyroid hormone in the body, and increase the effects and side effects of thyroid hormone. There are over 100 possible drug interactions with goldenseal, have your pharmacist check for drug interactions with all your medicines. Herbal supplements can interact with medicines used to treat heart and blood vessel problems, such as high blood pressure and heart failure. Chengappa KN, Bowie CR, Schlicht PJ, Fleet D, Brar JS, Jindal R. Randomized placebo-controlled adjunctive study of an extract of withania somnifera for cognitive dysfunction in bipolar disorder. The .gov means its official. Sedatives: Since ashwagandha can both energize and induce restorative sleep, it might negate or amplify the effect of other sedative drugs, especially the benzodiazepines. Supplements that may increase warfarin's blood-thinning effect (and consequently, the risk of abnormal bleeding) include: Supplements that may reduce warfarin's ability to thin the blood include: Join now to add comments and get all member benefits, including over 1,300 reviews. Investigation of CYP2B6, 3A4 and -esterase interactions of Withania somnifera (L.) dunal in human liver microsomes and HepG2 cells. Lexapro's interactions with ashwagandha. 8600 Rockville Pike Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network. Of course, theres more to the story that needs to be considered before adding a new supplement to your daily wellness routine. 2021;51(4):363-365. St. Johns Wort is a popular herbal supplement widely used to help with symptoms of depression. It may be used by some people to help with rheumatoid arthritis and nerve pain in diabetes, also called diabetic neuropathy.. Evening primrose oil provides fatty acids used by the body for growth. This feature is restricted to active members. Anbalagan K and Sadique J. Withania somnifera (ashwagandha), a rejuvenating herbal drug which controls alpha-2 macroglobulin synthesis during inflammation. There are 102 drugs known to interact with letrozole, along with 3 disease interactions, and 1 alcohol/food interaction. fractured ending scene; harold bornstein obituary cause of death; can you play volleyball with a torn acl; gambar teguh sugianto. View abstract. Can you take ashwagandha and Orilissa together? The use of the eHealthMe site and its content is at your own risk. Of the total drug interactions, 129 are major, 500 are moderate, and 16 are minor. Acta Nerv Super 1990;32(1):1-5. Mushroom tea is super simple. There are 626 drugs known to interact with Remeron (mirtazapine), along with 13 disease interactions, and 2 alcohol/food interactions. Chen W, Liu Y, Tang L, Li Z, Liu Y, Dang H. Medicine (Baltimore). As always, be sure to talk to your doctor about combining any over-the-counter dietary supplement with your prescribed drugs as they have your complete medical profile. There are 645 drugs known to interact with methotrexate, along with 5 disease interactions, and 3 alcohol/food interactions. View abstract. There's some early evidence that ashwagandha affects the immune system and helps reduce swelling, from both arthritis and fluid retention. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. Devi, P. U., Sharada, A. C., and Solomon, F. E. Antitumor and radiosensitizing effects of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma-180. Disclaimer. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Panda S, Kar A. View abstract. Taking ashwagandha with sedative medications might cause breathing problems and/or too much sleepiness. Valerian may also slow down how quickly certain drugs are broken down by the liver. Over 500 drug interactions exist with St. John's Wort and some can be dangerous. J.Transl.Med. View abstract. (DVT, pulmonary embolism, stroke, VTE, etc.) The interactions between warfarin and medicinal herbs described in the literature have been summarized in this paper relying on Medline database (via PubMed) using the key words: warfarin, herbal supplements and interactions. Indian J Exp Biol 2000;38:607-9. Does Remeron interact with my other drugs? Ugeskr Laeger. Visit our Top 9 Ways to Prevent a Deadly Drug Interaction slideshow and join the Drugs.com Herbal Support Group to ask questions about drug interactions, check on the latest medical news, and provide your honest feedback, too.